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Proving The Promise

Proving the promise



DePuy Synthes EMEA Launches ATTUNE Revision Knee System to Deliver Stability in Motion for More Patients

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ATTUNE® Knee System Value Analysis Brief

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The ATTUNE Knee is a total primary knee system designed with the goal of addressing the clinical needs of patients, surgeons and hospital providers around the world.

Extensive research and science has been included in the design to help improve functional outcomes for patients, performance for surgeons, and efficiency for providers.

The ATTUNE Knee is one of the largest research and development projects in the history of DePuy Synthes and combines the latest in design, kinematics, engineering and materials to deliver stability and motion .


ATTUNE total knee system was designed with the goal of addressing unmet clinical needs, helping improve outcomes and positively impacting patient satisfaction.



1. Association of American Retired Persons (AARP). Joint Replacement Surgery Patient Survey. 2007 September. Conducted in Boston, MA; September 6-8, 2007.

2. Baker PN, van der Meulen JH, Lewsey J, Gregg PJ. The Role of Pain and Function in Determining Patient Satisfaction After Total Knee Replacement. JBJS-Br. 2007; 89-B(7): 893-900


Developing a new system

DePuy Synthes is world renowned for its knowledge and development of successful knee replacement systems. Some of the iconic DePuy Synthes primary knees include the SIGMA® Knee System and the LCS™ Knee System.

Total knee replacement surgery can be a highly successful procedure . However, it is also a complex procedure. Surgeons are faced with varying patient anatomies and difficult intra-operative decisions each time they enter the operating room (OR).

At the same time, patients seek to return to the normal and active lifestyle they enjoyed prior to the onset of their joint disease.

Unfortunately, total knee patients are not always satisfied with their outcome and report differing levels of satisfaction following surgery. It is the goal of DePuy Synthes to design total knee systems that work with the surgeon to positively impact patient satisfaction .


Extensive research and science combining the latest in design kinematics, engineering and materials has been incorporated in the ATTUNE Knee System to deliver a high level of STABILITY IN MOTION.



To better understand what factors may lead to improved patient satisfaction, DePuy Synthes embarked on one of the largest research and development projects in its history.

DePuy Synthes' clinical heritage in knee replacement design is recognized in the industry. With this foundation in clinically proven design principles, the design team re-examined every aspect of knee implant and instrument design.

A world class surgeon team was assembled and working relationships with leading research facilities were established to study areas such as kinematics, anthropometrics, polyethylene wear, and instrument design.

The following system goals were established:

  • Improve function through motion and stability
  • Improve patient fit
  • Improve patello-femoral function
  • Improve design and materials for implant durability
  • Advance surgical process for implant positioning


Attune Gradius Curve

The patented ATTUNE GRADIUS Curve is designed with a gradually reducing femoral radius. This curve creates a smooth transition during knee bending and produces high stability of the knee by minimizing unnatural sliding of the femur on the tibia.

Click to view animation

SOFCAM Contact

For the Posterior Stabilized design, the interaction between the cam and spine, the articular surface geometry, and the collateral ligaments is complex and essential to the function of the knee in deep flexion. The proprietary s-curve design of the SOFCAM Contact provides a smooth engagement for gradual femoral rollback and stability in flexion, while reducing the forces transferred to the tibial spine.3

Click to view animation


Differentiated to current offerings, surgeons are able to match the femoral size to the insert size every time to achieve the highest conformity and optimized stability in early flexion. 4

Click to view animation

GLIDERIGHT Articulation

The patello-femoral interaction is one of the more challenging aspects of total knee arthroplasty. 5 The GLIDERIGHT Articulation encompasses a trochlear groove designed to accommodate patient variation and soft tissue interaction, and patella components designed to optimize patella tracking while maintaining bone coverage.

Click to view animation


To provide implant sizes that were reflective of the global patient population, DePuy Synthes collaborated with University College Dublin to conduct extensive anthropometric research. The ATTUNE Knee Femoral Sizing Line was created to accommodate the global patient population and avoid mediolateral overhang.

Click to view animation


The INTUITION Instruments were developed to deliver efficiencies for all stakeholders and an intuitive surgical process.

These innovative instruments work with the advancements in the implant design to help balance the soft tissues and precisely control the implant position and fit for each patient.

Click to view Precise Control Animation
Click to view Efficient Path Animation
Click to view Design Clarity Animation
  1. 3 Fitzpatrick, C. K., Clary, C. W., & Rullkoetter, P. J. (2012). Post-cam engagement during dynamic activity with current posterior stabilized TKR. 18th European Society of Biomechanics, Presentation Number 1700, Lisbon, Portugal
  2. 4 Fitzpatrick, C. K., Clary, C. W., & Rullkoetter, P. J. (2012). The influence of design on TKR mechanics during activities of daily living. Orthopaedic Research Society, 58th Annual Meeting, Poster Number 2034, San Francisco, CA
  3. 5 Amis, A. A., Senavongse, W., Bull, A. M. J. (2006). Patellofemoral kinematics during knee flexion-extension: an in vitro study. Journal of Orthopaedic Research, 24, 2201-2211


The ATTUNE evidence generation programme is the largest and most extensive in DePuy Synthes history.

Clinical Outcomes

Functional Outcomes

  • Learning Curve with a New Primary TKA Implant: A Worldwide Perspective with more than 2000 Patients
  • Patient Reported Outcomes in TKA Among Currently Available Products: A Large Sample Prospective Worldwide Study
  • Early Outcomes with a New Primary Total Knee Arthroplasty System vs. Contemporary TKA: Interim Results of Two Worldwide, Multi-Center Prospective Studies
  • An Early Outcome Study of the ATTUNE® Knee System vs. the SIGMA® CR150 Knee System
  • ATTUNE® Knee System Value Analysis Brief
  • Review of Dr. Takagi's Case Series Report of ATTUNE® Knee System

Early User Studies

  • Outcome of the First 500 Cases of a New Total Knee Replacement Prosthesis
  • An Early Outcome Study of the ATTUNE® Knee System vs. the SIGMA® CR150 Knee System
  • ATTUNE® Knee System Early Performance: Minimum Two Year Clinical Results White Paper
  • ATTUNE® Improved Survivorship Clinical Outcomes Over P.F.C. Sigma

Health Economics & Market Access (HEMA)

  • The Impact of Implant Design on Hospital Length of Stay and Discharge Destination ‐ Evidence Summary Report
  • Hospital Length of Stay and Discharge Dispositon after Primary Total Knee Arthroplasty – Whitepaper
  • Improving the Value of Primary Total Knee Arthroplasty: the ATTUNE Knee System
  • Comparitive Effectiveness of the ATTUNE Knee System vs the Triathlon Knee System – Whitepaper 
  • April 2017 Orthopedics Today ATTUNE Knee Supplement
  • Improving Patient Satisfaction Through Total Knee Athroplasty Design - Orthopedics today supplement 2014


  • United Kingdom Joint Registry Data

National Joint Registry Data

  • Analysis of Total Knee Replacement using the ATTUNE Knee System in the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man

Pre-Clinical Research & Development

  • Orthopedic Research Society - The ATTUNE Knee System: Conference Abstracts
  • ATTUNE Knee System: Stability in Total Knee Replacement - White Paper
  • ATTUNE Knee System: LOGICLOCK Tibial Base Central Locking Design - White Paper
  • ATTUNE Knee System: Cruciate Retaining Fixed Bearing Insert Wear – Whitepaper
  • ATTUNE Knee System: SOFCAM Contact – Whitepaper
  • ATTUNE Knee System: Cruciate Sacrificing Fixed Bearing – Whitepaper
  • Tibial Base Design Factors Affecting Tibial Coverage after total knee Arthroplasty Symmetric Versus Asymmetric Bases
  • ATTUNE Knee System: ATTUNE GRADIUS Curve – Whitepaper
  • ATTUNE Knee System: Gilderight Articulation - Whitepaper

Additional Resources

  • ATTUNE® Knee System Surgical Technique


DePuy Synthes value based healthcare team aim to improve clinical outcomes and patient experiences whilst improving efficiencies.



Our mission is to provide Hospitals with value-based healthcare solutions that augments the provision of "best-in-class" products, helping customers achieve the goals of the Triple Aim performance – sustainably.

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eSIMS Advanced Inventory Management Solution

Is designed to aid in the management and ordering of DePuy Synthes inventory by utilising the barcodes printed on sterile and non-sterile product packaging.

The eSIMS software is designed to improve efficiencies and optimise the supply chain by greatly reducing time, costs, resources, and errors throughout the inventory management and procurement process, helping to create the ‘perfect order’.

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Care4Today® Orthopedic Solutions is an end-to-end technology-enabled patient pathway program build on the principles of enhanced recovery. The solution is built around a modular approach: Audit, Change Management, Patient Education, Digital Patient Engagement, and PROMs, where we aim to design the best program to meet your needs.

Through this program we aim to deliver improved clinical outcomes, improved patient satisfaction and experience, and reduced costs.

Care4Today Theatre Efficiency Programme


Johnson and Johnson Medical Devices and DePuy Synthes share a common vision – providing the technologies and surgical training needed to improve the lives of patients all around the world. The best patient outcomes are achieved when surgeons have the right products along with the knowledge to use them safely and effectively. That’s why we’ve developed extensive professional education programs which have made us one of the leaders in surgeon training.


Visitation Centres (VCs) are an established part of the DePuy Synthes Professional Education Pathway for Healthcare Professionals (HCPs). They provide the respective HCP with an opportunity to visit a recognized Key Opinion Leader (KOL) at their practice/centre of excellence in small groups of 2 – 4 HCPs. The objective of each VC is to enable the visiting HCP to have a better understanding of a specific technique/procedure that may have previously been introduced at a DePuy Synthes course or on-line at

Educational Information

  • Guidance For Cementing Primary Total Knee Replacements


For additional information about any of the DePuy Synthes events please contact your local DePuy Synthes representative


There are multiple global, comprehensive studies, both company and independent initiated, designed to provide evidence in support of the ATTUNE Knee System.


DePuy Synthes EMEA Launches ATTUNE Revision Knee System to Deliver Stability in Motion for More Patients

Barcelona, Spain – 31 May 2018 – Comprehensive revision system designed to address broad range of Complex Primary and Revision procedures

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2018 News Articles

ATTUNE® Knee System Four-Year Revision Rate is Lower Than Total Knee Class, According to New & Independent Joint Registry Data

Leeds, UK – 10 May 2018 – Recent Evidence Shows Potential Positive Impact of Implant Design on Functional Outcomes and Hospital Discharge Status [Read more...]

2017 News Articles

ATTUNE® Knee System Four-Year Revision Rate is Lower Than Total Knee Class, According to New & Independent Joint Registry Data

Vienna, AT – 31 May 2017 – DePuy Synthes, part of the Johnson & Johnson Family of Companies, today announced new ATTUNE® Knee implant survivorship data based on an Implant Summary Report obtained from the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man (NJR). [Read more...]


National Joint Registry releases its Implant Summary Report for primary knee implants.

London, UK – 27 April 2017 – Today, the National Joint Registry released its Implant Summary Report for primary knee implants. [Read more...]


New report demonstrates the clinical and economic value of the Attune® Knee System in today’s value-based environment

London, UK – 20 April 2017 – Today, DePuy Synthes, part of the Johnson & Johnson Family of Companies, released the report, “Improving the Value of Primary Total Knee Arthroplasty: the ATTUNE® Knee System,” that analyzes the ATTUNE Knee’s current clinical and economic data. [Read more...]

2016 News Articles

Latest Australian Joint Registry Data Confirm Positive Early Results For the ATTUNE® Knee System.

Solothurn, Switzerland - 19 December 2016, DePuy Synthes, part of the Johnson & Johnson Family of Companies, today announced that implant survivorship [Read more...]


Latest UK joint registry data confirms positive early results for the DePuy Synthes ATTUNE® Knee System.

Solothurn, Switzerland – 29 November 2016, DePuy Synthes Joint Reconstruction, today announced the latest clinical evidence of the performance of the [Read more...]

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